MedStat Stutter

Phantasies of a physicist fallen among physicians

Summary

Time series from 13C breath test recordings are used as a surrogate indicator for gastric emptying. Gastric emptying half time t50 is computed by fitting the series with an exponential beta or a Gamma function. Often, records are too short to obtain stable estimates of the trailing part. One can easily get unrealistic emptying times when single curves are fitted (Ghoos et al. (1993), Maes et al. (1998)).

Population methods can come to the rescue. When these fail, Bayesian methods provide a robust approach to non-linear curve fitting.

Zipped source files and data

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Regression Mysteries

Dieter Menne 15 Juli 2017

In the paper by Hoad et al. (2015), two different methods to measure gastric content volume (GCV) were compared, by MRI and by gamma scintigraphy. A regression line was computed which is the best prediction of GCV(MRI) given GCV(Scintigraphy). The s...

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Gastric emptying can be recorded by scintigraphy or by MRI techniques. Scintigraphy returns times series data of the meal volume, MRI gives the total content of the stomach, which includes meal and secretion. To quantify secretion and emptying in clinical studies, non-linear curves are fitted to the time series, which can give strange results. When the ballot fails, the bazaar comes to the rescue.

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Summary

Using vectors for indexed access to ragged arrays in Stan

volume ~ normal(
      v0[record] .* (1+ kappa[record] .* (minute ./ tempt[record])) .*
      exp(-minute ./ tempt[record]), sigma);

Fitting gastric emptying time series

Gastric volume times serie measured by MRI techniques can have an initial volume overshoot due to secretion. To estimate half-times and the degree of overshoot, the author of this blog has introduced the linexp function [@Fruehauf2011] with three parameters to complement the power exponential function used in earlier research [@Elashoff1982, @Elashoff1983b] with scintigraphic data.

linexp:

v = v0* (1+t*kappa/tempt)*exp(-t/t_{empt})

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Excel eignet sich nur eíngeschränkt zur statistischen Auswertung klinischer Studien, aber zu Dateneingabe und Verwaltung bei medizinischen Studienarbeiten ist es durchaus geeignet. Hier einige Rezepte, von Muss sein bis Das Beste zum Schluss.

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